Пробиотики и продукты функционального питания
Аннотация
Цель обзора. Охарактеризовать лечебнопрофилактическое действие пробиотиков, понятие «функционального питания» и его значение в структуре питания человека.
Основное содержание. Лечебные и профилактические эффекты пробиотиков включают повышение устойчивости к инфекционным заболеваниям кишечника и дыхательных путей, предупреждение и сокращение продолжительности диареи, улучшение переносимости лактозы, лечение запора, уменьшение наклонности к атопическим реакциям и др. Применяемые штаммы могут оказывать прямое действие на проницаемость кишечного барьера и звенья иммунитета: повышают выработку иммуноглобулина А, влияют на активность фагоцитов и натуральных киллеров, выработку цитокинов, на сигнальные внутриклеточные молекулы. Некоторые лечебные штаммы снижают риск атопических реакций.
Штаммы, зарекомендовавшие себя как эффективные средства профилактики широко распространенных заболеваний, включают в состав функциональных продуктов питания. Кисломолочный продукт, обогащенный L. casei DN-114001 Imunitass, в контролируемых клинических исследованиях показал защитный эффект применительно к наиболее распространенным инфекционным заболеваниям.
Пробиотический кисломолочный продукт, обогащенный B. animalis DN-173 010 (ActiRegularis), имеет весомую доказательную базу в отношении положительного влияния на частоту стула.
Заключение. Применение пробиотиков имеет большие перспективы как «физиологичный» и безопасный способ стимуляции защитных резервов организма. Один из путей более широкой «эксплуатации» профилактического действия – включение в состав кисломолочных продуктов для ежедневного потребления.
Об авторе
Ю. О. ШульпековаРоссия
Список литературы
1. Горелов АВ, Усенко ДВ. Влияние пробиотического продукта «Актимель» на состояние здоровья детей. Вопросы современной педиатрии. 2003; 4(2):87–90.
2. Горелов АВ, Усенко ДВ, Елезова ЛИ, и др. Использование пробиотических продуктов в лечении кишечных инфекций у детей. Вопросы современной педиатрии. 2005; 2 (4):47–52.
3. Парфенов АИ, Ручкина ИН, Царегородцева ТМ, Серова ТИ. Клиническая эффективность продукта питания «Актимель» у больных синдромом раздраженного кишечника с преобладанием поносов. Эксперим клин гастроэнтерол. 2005; 5:45–52.
4. Радзинский ВЕ, Ордиянц ИМ. Роль Acimel в восстановлении нарушенного микробиоценоза половых органов беременных. Фарматека. 2006; 2:62–5.
5. Agarwal SK, Bhasin SK. Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi. Eur J Clin Nutr. 2002 Dec;56 Suppl 4:56–9.
6. Agrawal A, Houghton LA, Morris J, et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation // Aliment Pharmacol Ther. 2008 Sep 17 [Epub. ahead of print].
7. Anderson RC, Cookson AL, McNabb WC, et al. Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiol. 2010; 10:316.
8. Arpi M, Vancanneyt M, Swings J, Leisner JJ. Six cases of lactobacillus bacteraemia: Identification of organisms and antibiotic susceptibility and therapy. Scand J Infect Dis. 2003; 35 (6–7):404–8.
9. Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut. 2006; 55:1512–20.
10. Aubin JT, Remigy M, Verseil L, et al. Пробиотический ферментированный молочный продукт усиливает иммунный ответ на противогриппозную вакцинацию у пожилых людей/ Международном конгрессе по иммунологии (ICI), Рио-де-Жанейро, Бразилия, август 2007 г.
11. Bodera P., Chcialowski A. Immunomodulatory Effect of Probiotic Bacteria. Recent Patents on Inflammation & Allergy Drug Discovery. 2009; 3:58–64.
12. Boge T, Rémigy M, Vaudaine S, et al. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine. 2009 Sep 18; 27 (41):5677–84.
13. Chiang BL, Sheih YH, Wang LH, et al. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr. 2000; 54:849–55.
14. Chmielewska A., Szajewska H. Systematic review of randomised controlled trials: probiotics for functional constipation. World J Gastroenterol. 2010; 16 (1):69–75.
15. Claisse O, Lonvaud-Funel A. Primers and a specific DNA probe for detecting lactic acid bacteria producing
16. -hydroxypropionaldehyde from glycerol in spoiled ciders. J Food Prot. 2001; 64 (6):833–7.
17. Cobo Sanz JM, Mateos JA, Munoz Conejo A. Effect of Lactobacillus casei on the incidence of infectious conditions in children. Nutr Hosp. 2006; 21 (4):547–51.
18. Cookson WOCM, Moffatt MF. Asthma: An epidemic in the absence of infection? Science. 1997; 275:41–2.
19. Delcenserie V, Martel D, Lamoureux M, et al.
20. Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol. 2008; 10 (1):37–54.
21. Denholm J, Horne K, McMahon J, et al. Yoghurt consumption and damaged colonic mucosa: A case of Lactococcus lactis liver abscess in an immunocompetent patient. Scand J Infect Dis. 2006; 38:739–41.
22. De Paula JA, Carmuega E, Weill R. Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation. Acta Gastroenterol. Latinoam. 2008; 38 (1):16–25.
23. Drouault-Holowacz S, Bieuvelet S, Burckel A, et al. A double blind randomized controlled trial of a probiotic combination in 100 patients with rritable bowel syndrome. Gastroenterol Clin Biol 2008; 32 (2): 147–52.
24. Dykstra NS, Hyde L, Adawi D, et al. Pulse Probiotic administration induces repeated small intestinal MUC3 expression in rats. Pediatr Res. 2011; 69:206–11.
25. Ewaschuk J, Diaz H, Meddings L, et al. Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J Physiol Gastrointest Liver Physiol. 2008; 295:1025–34.
26. Food and Agriculture Organization, World Health Organization. The Food and Agriculture Organization of the United Nations and the World Health Organization Joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. FAO/ WHO Report No. 4-30-2002.
27. Fujiya M, Musch MW, Nakagawa Y, et al. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007; 1:299–308.
28. Ghadimi D, Fólster-Holst R, de Vrese M, et al. Effects of probiotic bacteria and their genomic DNA on TH1/TH2-cytokine production by peripheral blood mononuclear cells (PBMCs) of healthy and allergic subjects. Immunobiology. 2008; 213 (8):677–92.
29. Gluck U, Gebbers JO. Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic streptococci). Am J Clin Nutr. 2003; 77:517–20.
30. Guillemard E, Tanguy J, Flavigny A, et al. Effects of consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 on common respiratory and gastrointestinal infections in shift workers in a randomized controlled trial. J Am Coll Nutr. 2010; 29 (5):455–68.
31. Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010 Jan; 103 (1):58-68.
32. Hasler CM, Brown AC. Academy of Nutrition and Dietetics. «Position of the Academy of Nutrition and Dietetics: functional foods.» J Am Diet Assoc. 2009 Apr;109 (4):735-46.
33. Hatakka K, Saxelin M. Probiotics in intestinal and nonintestinal infectious diseases – Clinical evidence. Curr Pharm Des. 2008; 14 (14):1351–67.
34. Hickson M, D’Souza A, Muthu N, et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ. 2007; 335:80–5.
35. Isolauri E. Studies on Lactobacillus GG in food hypersensitivity disorders. Nutr Today Suppl. 1996; 31:285–315.
36. Isolauri E, Joensuu J, Suomalainen H, et al. Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine. 1995; 13:310–2.
37. Isolauri E, Sutas Y, Kankaanpaa P, et al. Probiotics: effects on immunity. Am J Clin Nutr. 2001; 73 (2 Suppl):
38. –50.
39. Kaila M, Isolauri E, Soppi E, et al. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr Res. 1992; 32:141–4.
40. Kankainen M, Paulin L, Tynkkynen S, et al. Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human-mucus binding protein. Proc Natl Acad Sci USA. 2009; 106:17193–8.
41. Kankaanpää P, Sütas Y, Salminen S, Isolauri E. Homogenates derived from probiotic bacteria provide downregulatory signals for peripheral blood mononuclear cells. Food Chem. 2003; 83:269–77.
42. Khailova L, Mount PSK, Arganbright KM, et al. Bifidobacterium bifidum reduces apoptosis in the intestinal epithelium in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2010; 299:1118–27.
43. Kiessling, G; Schneider J, Jahreis G. Long term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr. 2002; 56 (9):843–9.
44. Lenoir-Wijnkoop I, Sanders ME, Cabana MD, et al. Probiotic and prebiotic influence beyond the intestinal tract. Nutr Rev. 2007; 65 (11):469–89.
45. Link-Amster H, Rochat F, Saudan KY, et al. Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol. 1994; 10:55–63.
46. Lutgendorff F, Nijmeijer RM, Sandstrom PA, et al. Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis. PLoS ONE. 2009; 4:4512.
47. Madsen KL. Enhancement of Epithelial Barrier Function by Probiotics. J Epithelial Biol. Pharmacol. 2012; 5 (Suppl 1-M8):55–9.
48. Madsen K, Cornish A, Soper P, et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001; 12:580–91.
49. Majamaa H, Isolauri E, Saxelin M, et al. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 1995; 20:333–9.
50. Marcos A, et al. The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN 114-001 on the immune response of subjects under academic examination stress. Eur J Nutr. 2004 Dec; 43 (6):381–9.
51. Mathias A, Duc M, Favre L, et al. Potentiation of polarized intestinal Caco-2 cell responsiveness to probiotics complexed with secretory IgA. J Biol Chem. 2010; 285:33906–13.
52. Meance S, et al. Recent advance in the use of functional foods: Effect of the commercial fermented milk with Bifidobacterium animalis strain DN–173 010 and yogurt strains on gut transit time in the elderly. Microb. Ecology Health Dis. 2003; 15:15–22.
53. Merenstein D, Murphy M, Fokar A, et al. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114001) to decrease the rate of illness in kids: the DRINK study. Eur J Clin Nutr. 2010 Jul; 64 (7):669–77.
54. Meyer AL, Elmadfa I, Herbacek I, Micksche M. Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. J Hum Nutr Diet. 2007; 20 (6):590–8.
55. Pagnini C, Saeed R, Bamias G, et al. Probiotics promote gut health through stimulation of epithelial innate immunity. Proc Natl Acad Sci USA. 2010; 107:454–9.
56. Parra D, Martinez de Morentin B, Cobo JM, et al. Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei. J Nutr Health Aging. 2004; 8 (4):208–11.
57. Parvez S, Malik KA, AhKang S, Kim H-Y. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. 2006; 100:1171–85.
58. Pedone CA, Arnaud CC, Postaire ER, et al. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea. Int J Clin Prac. 2000; 54 (9):568–71.
59. Pedone CA, Bernabeu AO, Postaire ER, et al. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Prac. 1999; 53 (3):179–84.
60. Pelto L, Isolauri E, Lilius EM, et al. Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clin Exp Allergy. 1998; 28 (12):1474–9.
61. Pelto L, Salminen S, Lilius EM, et al. Milk hypersensitivity – key to poorly defined gastrointestinal symptoms in adults. Allergy. 1998; 53:307–10.
62. Pereg D, et al. The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population. Am J Infect Control. 2005 Mar; 33 (2):122–5.
63. Probiotics and prebiotics. World Gastroenterology Organisation, 2008. Интернет-сайт http://www. worldgastroenterology.org/assets/downloads/en/pdf/ guidelines/ 19_probiotics_prebiotics.pdf.
64. Pujol P. et al. The effect of fermented milk containing Lactobacillus casei on the immune response to exercise. Training and Rehab, 9:209–23.
65. Resta-Lenert S, Barrett KE. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC). Gut. 2003; 52:988–97.
66. Rinne M, Kalliomaki M, Arvilommi H, et al. Effect of probiotics and breastfeeding on the Bifidobacterium and Lactobacillus/enterococcus microbiota and humoral immune responses. J Pediatr. 2005; 147:186–91.
67. Rochet V, et al. Effects of orally administered Lactobacillus casei DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans. Br J Nutr. 2006; 95:421–9.
68. Rosenfeldt V, Michaelsen KF, Jakobsen M, et al. Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea. Pediatr Infect Dis J. 2002; 21:411–6.
69. Saavedra JM, Bauman NA, Oung I, et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994; 344:1046–9.
70. Salva S, Villena J, Alvarez S. Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: Impact on intestinal and respiratory infections. Int J Food Microbiol. 2010; 141 (1–2):82–9.
71. Schiffrin EJ, Rochat F, Link-Amster H, et al. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci. 1994; 78:491–7.
72. Sykora J, Malan A, Zahlava J, et al. Gastric emptying of solids in children with H. pylori-positive and H. pylorinegative non-ulcer dyspepsia. J Pediatr Castroenterol Nutr. 2004; 39:246–52.
73. Tabbers MM, Chmielewska A, Roseboom MG, et al. Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre randomised controlled trial (NTRTC: 1571). BMC Pediatr. 2009; 18 (9):22.
74. Tao Y, Drabik KA, Waypa TS, et al. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006; 290:1018–30.
75. Turchet P, Laurenzano M, Auboiron S, Antone JM. Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomized, controlled pilot study. J Nutr Heal Agin. 2003; 2 (7):75–7.
76. U.S. Food and Drug Administration. «Claims That Can Be Made for Conventional Foods and Dietary Supplements». Accessed August 16, 2011. Интенетсайт http://www.fda.gov/Food/LabelingNutrition/ LabelClaims/ucm111447.htm.
77. Yan F, Cao H, Cover TL, et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology. 2007; 132:562–75.
78. Yan F, Polk DB. Probiotic bacterium prevents cytokineinduced apoptosis in intestinal epithelial cells. J Biol Chem. 2002; 277:50959–65.
Рецензия
Для цитирования:
Шульпекова Ю.О. Пробиотики и продукты функционального питания. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2012;22(3):70-79.
For citation:
Shulpekova Yu.О. Probiotics and functional nutrition products. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2012;22(3):70-79. (In Russ.)

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